To examine wholebrain connectivity patterns, modelfree methods have been introduced, enabling the exploration of connectivity patterns without the need of defining an a priori seed region In contrast to seedbased methods, modelfree methods are designed to look for general patterns of (unique) connectivity across brain regionsHoney et al, 09Seedbased connectivity metrics characterize the connectivity patterns with a predefined seed or ROI (Region of Interest) These metrics are often used when researchers are interested in one, or a few, individual regions and would like to analyze in detail the connectivity patterns between these areas and the rest of the brain
Resting State Functional Mri Everything That Nonexperts Have Always Wanted To Know American Journal Of Neuroradiology
